"Accelerating pathology image data cross-comprison on CPU-GPU hybrid systems", Kaibo Wang, Yin Huai, Rubao Lee, Fusheng Wang, Xiaodong Zhang, and Joel H. Saltz Proceedings of 38th International Conference on Very Large Databases (VLDB 2012), Istanbul, Turkey, August 27-31, 2012. Abstract As an important application of spatial databases in pathology imaging analysis, cross-comparing the spatial boundaries of a huge amount of segmented micro-anatomic objects demands extremely data- and compute-intensive operations, requiring high throughput at an affordable cost. However, the performance of spatial database systems has not been satisfactory since their implementations of spatial operations cannot fully utilize the power of modern parallel hardware. In this paper, we provide a customized software solution that exploits GPUs and multi-core CPUs to accelerate spatial cross-comparison in a cost-effective way. Our solution consists of an efficient GPU algorithm and a pipelined system framework with task migration support. Extensive experiments with real-world data sets demonstrate the effectiveness of our solution, which improves the performance of spatial cross-comparison by over 18 times compared with a parallelized spatial database approach.